Gyno Reversal Protocol (AI + SERM + Bloodwork-Based Adjustments)

Step 1: Bloodwork (Before Adjusting Anything)

To tailor the protocol, get the following tests ASAP:

✔ Estradiol (E2, sensitive test)

✔ Prolactin & Progesterone

✔ Total & Free Testosterone

✔ Liver Function Tests (ALT, AST, GGT, etc.)

• If E2 is still high, we adjust the AI dose.

• If prolactin is high, we add Cabergoline (Dostinex) or Pramipexole.

  
  

Step 2: Core Gyno Reversal Stack

1️⃣ Raloxifene – The Primary Reversal Agent

• Dose: 60mg/day (Taken in the morning)

• Duration: 8-12 weeks

• Why? Selective Estrogen Receptor Modulator (SERM) that actively blocks estrogen in breast tissue and can shrink existing gyno. Studies support its effectiveness over Tamoxifen (Nolvadex).

  
  

2️⃣ Aromatase Inhibitor (AI) – Control Estrogen at the Source

• Option 1 (Mild to Moderate Estrogen Suppression):

  • Arimidex (Anastrozole) 0.5mg every other day

  • Increase to 0.5mg daily if E2 is still high

• Option 2 (More Effective, No Estrogen Rebound):

  • Aromasin (Exemestane) 12.5mg every other day

  • Increase to 12.5mg daily if needed

  • Why? Unlike Arimidex, Aromasin permanently destroys aromatase enzymes, reducing rebound risk.

    
    

✅ AI Notes:

• Don't crush E2 to zero—estrogen is essential for joints, mood, and libido.

• Adjust AI dosing based on follow-up bloodwork (2-3 weeks after starting).

  
  

3️⃣ Prolactin Control (If Needed)

📌 Only add Cabergoline (Dostinex) if prolactin is high (>20 ng/mL).

• Cabergoline 0.25mg twice per week

• Monitor prolactin levels after 3-4 weeks and adjust accordingly.

  
  

Step 3: Lifestyle & Supplementary Measures

1️⃣ Lower Body Fat %

• Higher body fat → More aromatization → More estrogen → More gyno.

• Aim for 10-12% BF for optimal hormonal balance.

2️⃣ Reduce Alcohol & Excess Carbs

• Both increase aromatase activity & estrogen.

3️⃣ Liver Health = Estrogen Metabolism

• Use TUDCA or NAC (1200mg/day) to support liver detox of excess estrogen.

4️⃣ Zinc + Vitamin B6 (P5P) to Reduce Prolactin

• Zinc (50mg/day) + Vitamin B6 (100mg/day P5P form) helps naturally lower prolactin.

  
  

Step 4: Monitor & Adjust (Timeline)

✔ Weeks 1-2: Start Raloxifene + AI, monitor symptoms.✔ Weeks 3-4: Recheck estradiol & prolactin levels. Adjust AI dose if needed.✔ Weeks 6-8: Evaluate gyno reduction. Continue if improvement.✔ Weeks 10-12: If resolved, taper off Raloxifene slowly. Maintain AI if needed.

Expected Results

• Week 2-3: Reduction in sensitivity/swelling.

• Week 4-6: Noticeable shrinkage.

• Week 8-12: Significant improvement or near elimination.

  
  

📌 If gyno persists after 12 weeks, it may be fibrotic (hardened) tissue—only removable by surgery.

Final Notes

• If AI isn’t working, switch from Arimidex → Aromasin.

• If prolactin is high, add Cabergoline.

• If no improvement in 12 weeks, surgical removal is the only solution.